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August 1, 1993Clinical Science

Independent, Marked Associations of Alleles of the Insulin Receptor and Dipeptidyl Carboxypeptidase-1 Genes with Essential Hypertension

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Authors

BMBrian J. MorrisNYU Langone HealthRZRobert Y.L. ZeeRoche (Switzerland)LYLihua YingStanford University

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Implication

Cross-sectional study reveals independent associations of insulin receptor and dipeptidyl carboxypeptidase-1 alleles with essential hypertension, indicating distinct genetic risk factors.

Key Points

  • To investigate whether specific polymorphisms in candidate genes regulating blood pressure are genetically associated with essential hypertension.
  • Conducted cross-sectional analyses of candidate gene markers in hypertensive and normotensive subjects selected according to parental blood pressure status.
  • Tested differences in total chromosome alleles for each polymorphism between hypertensive and normotensive groups using chi-square analysis with one degree of freedom.
  • Hypertension was strongly associated with insertion alleles of the insulin receptor gene (INSR, P < 0.0040) and the dipeptidyl carboxypeptidase-1 gene (DCP1, P < 0.0018).
  • No significant associations were observed for polymorphisms of growth hormone, LDL receptor, renal kallikrein, alpha 2-adrenoreceptor, beta 1-adrenoreceptor, atrial natriuretic factor, or insulin genes.
  • Nearly all hypertensive subjects carried at least one risk allele, and subjects homozygous for both alleles were three times more frequent among hypertensives, indicating INSR and DCP1 act as independent markers.

Cite This Study

Morris et al. (1993) studied this question.

synapsesocial.com/papers/6a884494138f07bd6f14b8eahttps://doi.org/10.1042/cs0850189
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evidence for single gene contributions to hypertension and lipid disturbances: definition, genetics, and clinical significance1994 · 31 citations
  2. 2POLYMORPHISMS OF CANDIDATE GENES IN ESSENTIAL HYPERTENSION1992 · 16 citations
  3. 3SIMILARITY OF BLOOD PRESSURE FOR EACH GENOTYPE OF THE INSERTION/DELETION POLYMORPHISM OF THE DIPEPTIDYL CARBOXYPEPTIDASE‐1 GENE IN DIFFERENT AGE GROUPS OF PATIENTS WITH SEVERE, FAMILIAL ESSENTIAL HYPERTENSION1994 · 7 citations
  4. 4ACE I/D genetic polymorphism as a risk factor of essential hypertension2022 · 8 citations
  5. 5ACE I/D genetic polymorphism as a risk factor of essential hypertension2022 · 7 citations