Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 2022Health Risk AnalysisOpen Access

ACE I/D genetic polymorphism as a risk factor of essential hypertension

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Examining genetic mechanisms of essential hypertension could enable personalized early diagnostics and improve preventive strategies to reduce population mortality.

Is the ACE I/D gene polymorphism associated with an increased risk of essential hypertension?

Population

35 people with essential hypertension and 34 relatively healthy people

Comparison

Patients with diagnosed essential hypertension vs relatively healthy reference group

Design

Case-control study

Authors

KSK.G. StarkovaFederal Scientific Center for Medical and Preventive Health Risk Management TechnologiesОDО.V. DolgikhFederal Scientific Center for Medical and Preventive Health Risk Management TechnologiesОKО.А. KazakovaFederal Scientific Center for Medical and Preventive Health Risk Management Technologies

Discussion

Loading...

Member takes

Implication

Hypothesis-generating for ACE I/D polymorphism in essential hypertension risk; leaves open validation before any clinical use.

Structured PICO

Is the ACE I/D gene polymorphism associated with an increased risk of essential hypertension?

P
Population
69 individuals, including 35 with diagnosed essential hypertension and 34 relatively healthy controls.
I
Intervention
Carriage of the D-allele of the ACE I/D gene polymorphism (rs4646994)
C
Comparator
Non-carriers / relatively healthy reference group
O
Outcome
Risk of essential hypertension

The D-allele of the ACE I/D gene polymorphism is associated with an increased risk of essential hypertension and may serve as a potential marker of susceptibility.

Cite This Study

Starkova et al. (2022) studied this question.

synapsesocial.com/papers/6a90d810d2f2d69b3a744721https://doi.org/10.21668/health.risk/2022.3.16.eng
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ACE I/D genetic polymorphism as a risk factor of essential hypertension2022 · 7 citations
  2. 2Association between angiotensin converting enzyme gene polymorphism and essential hypertension: A systematic review and meta-analysis2021 · 49 citations
  3. 3The Effect of ACE I/D Polymorphisms Alone and With Concomitant Risk Factors on Coronary Artery Disease2016 · 55 citations
  4. 4Angiotensin-converting enzyme insertion/deletion polymorphism association with obesity and some related disorders in Egyptian females: a case-control observational study2016 · 15 citations
  5. 5The association between the insertion/deletion polymorphism of the angiotensin converting enzyme gene and hypertension, as well as environmental, biochemical and anthropometric factors2020 · 10 citations