Key result
Carrying the DD genotype of the ACE gene I/D polymorphism increased the probability of developing essential hypertension in men by 1.9 times (OR 1.89; 95% CI 1.04-3.44; p=0.04).
Why the study?
The study was conducted to determine the impact of the I/D polymorphism of the ACE gene on the development of essential hypertension, taking into account gender differences.
Is the I/D polymorphism of the ACE gene associated with the development of essential hypertension?
Population
602 individuals (401 patients with essential hypertension and 201 controls) from the Belarusian ethnic group
Comparison
Patients with essential hypertension vs control group (and genotypes II, ID, DD)
Design
Case-control molecular genetic study
Authors
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Association in Belarusian men should not change practice; leaves open causal role and need for prospective validation.
Case-Control (n=602)
Is the I/D polymorphism of the ACE gene associated with the development of essential hypertension?
Effect estimate: OR 1.89 (95% CI 1.04-3.44)
Absolute Event Rate: 28.4% vs 17.3%
p-value: p=0.04
The DD genotype of the ACE gene is significantly associated with an increased risk of developing essential hypertension and a higher prevalence of premature cardiovascular disease heredity in Belarusian men.
Павлова et al. (2019) conducted a case-control in Essential hypertension (n=602). DD genotype of the ACE gene I/D polymorphism vs. II and ID genotypes was evaluated on Development of essential hypertension in men (OR 1.89, 95% CI 1.04-3.44, p=0.04). Carrying the DD genotype of the ACE gene I/D polymorphism increased the probability of developing essential hypertension in men by 1.9 times (OR 1.89; 95% CI 1.04-3.44; p=0.04).
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