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May 1, 1992Clinical and Experimental Pharmacology and Physiology

Polymorphisms of Candidate Genes in Essential Hypertension

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Why the study?

Are restriction fragment length polymorphisms in candidate genes (renin, haptoglobin, neuropeptide Y, and cardiac myosin beta heavy chain) associated with essential hypertension?

Population

Unspecified population assessed for essential hypertension

Design

Other

Authors

MWMalcolm WestAdult Congenital Heart DiseaseKSKim SummersTranslational Research InstitutePHP. R. HuggardThe University of Queensland

Discussion

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Implication

No association in this candidate-gene study; leaves open polygenic contributions to essential hypertension and requires larger validation.

Structured PICO

Are restriction fragment length polymorphisms in candidate genes (renin, haptoglobin, neuropeptide Y, and cardiac myosin beta heavy chain) associated with essential hypertension?

P
Population
Unspecified population assessed for essential hypertension
I
Intervention
Assessment of restriction fragment length polymorphisms of candidate genes (renin, haptoglobin, neuropeptide Y, and cardiac myosin beta heavy chain)
O
Outcome
Association between alleles at candidate loci and the presence of hypertensionsurrogate

Polymorphisms in the renin, haptoglobin, neuropeptide Y, and cardiac myosin beta heavy chain genes do not appear to significantly contribute to the genetic variance of essential hypertension.

Cite This Study

West et al. (1992) studied this question.

synapsesocial.com/papers/6a90330d1dcd98381b83ff84https://doi.org/10.1111/j.1440-1681.1992.tb00461.x

Topics

Hypertension managementHypertrophic cardiomyopathy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cosegregation of hypertrophic cardiomyopathy and a fragile site on chromosome 16 in a large Italian family.1990 · 12 citations
  2. 2Hypertension: Pathophysiology, Diagnosis, and Management1991 · 948 citations
  3. 3A lack of genetic linkage of renin gene restriction fragment length polymorphisms with human hypertension.1989 · 116 citations
  4. 4HinfI RFLP at the human renin (REN) gene locus1989 · 25 citations
  5. 5Current trends in mapping human genes1991 · 59 citations