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November 1, 1994Clinical and Experimental Pharmacology and Physiology

Similarity of Blood Pressure for Each Genotype of the Insertion/Deletion Polymorphism of the Dipeptidyl Carboxypeptidase‐1 Gene in Different Age Groups of Patients With Severe, Familial Essential Hypertension

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Why the study?

Does the I/D polymorphism of the DCP1 gene affect blood pressure in patients with severe, familial essential hypertension?

Population

Patients with severe, familial essential hypertension living in Sydney, stratified by age groups.

Comparison

DCP1 gene insertion/deletion polymorphism… vs Comparison between the different genotypes

Design

Cross-sectional

Authors

BMBrian J. MorrisThe University of SydneyRZRobert Y.L. ZeeRoche (Switzerland)

Discussion

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Implication

No association of DCP1 I/D genotypes with pretreatment BP in severe familial hypertension; leaves open effects on treatment response or progression.

Structured PICO

Does the I/D polymorphism of the DCP1 gene affect blood pressure in patients with severe, familial essential hypertension?

P
Population
Patients with severe, familial essential hypertension living in Sydney, stratified by age groups (< 50, 50-59 and >= 60 years).
I
Intervention
DCP1 gene insertion/deletion (I/D) polymorphism genotypes (II, ID, DD)
C
Comparator
Comparison between the different genotypes (II vs ID vs DD)
O
Outcome
Pretreatment systolic and diastolic blood pressuresurrogate

The study found no evidence of a genetic association between the I/D polymorphism of DCP1 and blood pressure severity in patients with familial hypertension.

Cite This Study

Morris et al. (1994) studied this question.

synapsesocial.com/papers/6a775f437ecc675f86ae632dhttps://doi.org/10.1111/j.1440-1681.1994.tb02467.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Independent, Marked Associations of Alleles of the Insulin Receptor and Dipeptidyl Carboxypeptidase-1 Genes with Essential Hypertension1993 · 43 citations
  2. 2Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus.1994 · 229 citations
  3. 3Insertion /deletion (I/D) polymorphism at the locus for angiotensin I‐converting enzyme and parental history of myocardial infarction1993 · 59 citations
  4. 4Angiotensin I-converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in T-lymphocytes1993 · 516 citations
  5. 5An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.1990 · 3,817 citations