Why the study?
Does the angiotensin converting enzyme gene polymorphism influence blood pressure elevation in arterial hypertension when accounting for cardiovascular risk factors?
Population
171 patients with abnormal clinic and 24 h ambulatory blood pressures, mean age 49 +/- 9 years, 61 women
Comparison
Angiotensin converting enzyme gene… vs Comparison between genotypes and…
Design
Cross-sectional
Authors
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ACE insertion allele linked to lower ambulatory BP only without other risks; leaves open utility for hypertension phenotyping or risk stratification.
Does the angiotensin converting enzyme gene polymorphism influence blood pressure elevation in arterial hypertension when accounting for cardiovascular risk factors?
The angiotensin converting enzyme insertion allele is associated with lower ambulatory systolic and pulse blood pressures in hypertensive patients only when additional cardiovascular risk factors are absent.
Celentano et al. (1998) studied this question.
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