Key result
In smokers, carrying two copies of the ACE D allele was associated with a significantly increased risk of hypertension (OR 1.5; 95% CI 1.1-2.2; P=0.02) compared to non-carriers.
Why the study?
Does the ACE I/D polymorphism affect blood pressure and the risk of hypertension differently based on smoking status?
Cohort (n=6,714)
Does the ACE I/D polymorphism affect blood pressure and the risk of hypertension differently based on smoking status?
Odds Ratio: 1.5 (95% CI 1.1–2.2)
p-value: p=0.02
The D allele of the ACE I/D polymorphism is associated with increased systolic blood pressure and risk of hypertension specifically in current smokers, highlighting a significant gene-environment interaction.
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May support gene-smoking interaction hypothesis; leaves open whether ACE genotyping informs hypertension prevention or care.
Schut et al. (2004) conducted a cohort in Hypertension (n=6,714). ACE insertion/deletion (I/D) polymorphism (D allele) vs. II carriers (non-carriers of the D allele) was evaluated on Risk of hypertension in smokers carrying two copies of the D allele (OR 1.5, 95% CI 1.1 to 2.2, p=0.02). In smokers, carrying two copies of the ACE D allele was associated with a significantly increased risk of hypertension (OR 1.5; 95% CI 1.1-2.2; P=0.02) compared to non-carriers.
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