Why the study?
Does the ACE-DD genotype increase the incidence of hypertension and cardiovascular events in healthy subjects?
Population
684 healthy volunteers, normotensive and free of cardiovascular diseases, with normal ECG and echocardiogram…
Comparison
ACE-DD genotype vs ACE-ID and ACE-II genotypes
Design
Cohort
Follow-up
6 years
Authors
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ACE-DD genotype was associated with higher hypertension and events; hypothesis-generating and requires prospective validation before clinical use.
Does the ACE-DD genotype increase the incidence of hypertension and cardiovascular events in healthy subjects?
The ACE-DD genotype is associated with a significantly higher incidence of hypertension and cardiovascular events in initially healthy subjects over a 6-year follow-up.
Pasquale et al. (2003) studied this question.
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