November 1, 1996Journal of Cerebral Blood Flow & MetabolismOpen Access

Brief Hypercapnia Enhances Somatosensory Activation of Blood Flow in Rat

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Why the study?

Does brief hypercapnia enhance somatosensory activation of blood flow in rats?

Population

Chloralose-anesthetized, mechanically ventilated rats

Comparison

Brief hypercapnia followed by somatosensory… vs Control conditions

Design

Preclinical

Follow-up

up to 60 minutes after hypercapnia

Authors

BSBernd SchmitzBundeswehrkrankenhaus BBBernd W. BöttigerUniversity of Cologne KHKonstantin‐Alexander HossmannMax Planck Institute for Metabolism Research

Discussion

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Implication

May augment neurovascular coupling in rodent models; leaves open translation to human cerebrovascular reactivity.

Structured PICO

Does brief hypercapnia enhance somatosensory activation of blood flow in rats?

Population

Chloralose-anesthetized, mechanically ventilated rats

Intervention

Brief hypercapnia (ventilation with 6% CO2 for 3 min) followed by somatosensory stimulation (electrical stimulation of the forepaw)

Comparator

Control conditions (somatosensory stimulation before hypercapnia)

Outcome

Somatosensory activation of blood flow measured in the contralateral primary somatosensory cortex by laser-Doppler flowmetry (LDF)surrogate

Brief hypercapnia produces a marked, long-lasting up-regulation of somatosensory activation of cerebral blood flow in rats.

Cite This Study

Schmitz et al. (1996) studied this question.

synapsesocial.com/papers/6a8a6794f8670bac6e337534 https://doi.org/10.1097/00004647-199611000-00027

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Brief Hypercapnia Enhances Somatosensory Activation of Blood Flow in Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Brief Hypercapnia Enhances Somatosensory Activation of Blood Flow in Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider