In untreated type 2 diabetes, subclinical inflammation and oxidative stress are primarily driven by lipid and glucose metabolism abnormalities rather than traditional demographic factors.
Metabolic drivers may predominate in T2D inflammation; hypothesis-generating and should not yet change practice.
Inflammation and oxidative stress play an important role in diabetes type 2 development and its complications. Inflammation is believed to be a connecting point between metabolic changes and cardiovascular diseases. The aim of the study was to investigate inflammation and oxidation as well as adiponectin level in untreated diabetic patients. In 158 patients the level of leucocytes, TNF-alfa, interleukins-1в, 4, and 6 were measured together with adiponectin, maalonic dialdegid, and sulfhydrated radicals. Male gender, dyslipidemia, metabolic syndrome were associated with increased level of uric acid and low level of adiponectin. Lipid and glucose metabolism abnormalities were related to oxidation activity without any association with antioxidation response. Adiponectin level was not related to inflammatory markers. Regression analysis revealed that inflammation markers and oxidative stress are not related to gender, age, smoking status and blood pressure but are determined by lipid and glucose metabolism.
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Kobalava et al. (2008) studied this question.
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