Key result
T2DM is linked to altered inflammatory cytokines including decreased IL-6 and TNF-α and increased IL-10.
Why the study?
The study aimed to assess inflammatory markers in type 2 diabetes mellitus by measuring cytokine concentrations and lymphocyte subsets and correlating them with laboratory investigations.
Comparison
Type 2 diabetes patients vs healthy volunteers
Design
Case-control study
Authors
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Cytokine shifts in T2DM may reflect immune dysregulation; hypothesis-generating and should not yet change practice.
Case-Control (n=87)
Type 2 diabetes is associated with significant alterations in immune system function and inflammatory cytokine profiles.
Al-Shukaili et al. (2013) conducted a case-control in Type 2 diabetes mellitus (n=87). Type 2 diabetes mellitus vs. Healthy volunteers was evaluated on Cytokine concentrations and lymphocyte subsets. Type 2 diabetes mellitus was associated with decreased IL-1β, IL-6, IL-15, and TNF-α, and increased IL-10, IFN-γ, and caspase-1 compared to healthy controls.
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