Key result
Inflammatory mediators TNF-α and IL-6 showed a positive correlation with type 2 diabetes mellitus and insulin sensitivity.
Why the study?
Low grade inflammation and upregulation of inflammatory mediators have been purported to play a significant role in the pathogenesis of T2DM.
Observational
TNF-α and IL-6 show a positive correlation with T2DM and insulin sensitivity, suggesting their potential as early prediction biomarkers.
Low grade inflammation and up regulation of inflammatory mediators has been purported to play a significant role in pathogenesis of T2DM. Our findings confirm that positive correlation of TNF-α and IL-6 with T2DM and insulin sensitivity. These can act as early prediction biomarkers of T2DM. Further studies on wider range of pro and anti- inflammatory cytokines i.e. mediators, in association with other biochemical, immunoassay and hematological parameters are needed to help clinicians manage and treat T2DM effectively.
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Bashir et al. (2020) conducted an observational in Type 2 diabetes mellitus. Inflammatory mediators (TNF-α, IL-6) was evaluated on Correlation with T2DM and insulin sensitivity. Inflammatory mediators TNF-α and IL-6 showed a positive correlation with type 2 diabetes mellitus and insulin sensitivity.
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