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February 14, 2025International Journal of Bipolar DisordersOpen Access

Prospects for lithium treated patients with severe renal impairment

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Why the study?

The prospects for lithium-treated patients who develop end-stage renal disease and the role of renal replacement therapy were not well defined.

Does continuing lithium treatment affect survival in lithium-treated patients who develop CKD4?

Population

620 adult patients with a lithium history and at least one eGFR < 30 ml/min/1.73 m2

Comparison

Continuing vs stopping lithium treatment after CKD4 debut

Design

Retrospective database analysis

Authors

HAHarald AiffSahlgrenska University HospitalPAPer-Ola AttmanRegion Västra GötalandMGMihaela GolicVarberg Hospital

Discussion

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Member takes

Overview

Survival after CKD4 spans years with or without continued lithium; leaves open optimal management pending prospective data.

Structured PICO

Does continuing lithium treatment affect survival in lithium-treated patients who develop CKD4?

P
Population
620 adult patients with a lithium history and at least one measurement of eGFR < 30 ml/min/1.73 m2, selected from a database of 4396 patients with a lithium history from 1980 to 2017.
I
Intervention
Continued lithium treatment (in the subgroup of patients who developed CKD4)
C
Comparator
Stopped lithium treatment
O
Outcome
Survival after the debut of CKD4hard clinical

In lithium-treated patients who develop CKD4, continuing lithium treatment does not significantly affect survival compared to stopping it.

Cite This Study

Aiff et al. (2025) studied this question.

synapsesocial.com/papers/6a8a6b056fc170cbc2fbebbchttps://doi.org/10.1186/s40345-025-00372-z
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Also Consider

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  1. 1KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease2024 · 8,296 citations
  2. 2Revised equations for estimating glomerular filtration rate based on the Lund-Malmö Study cohort2011 · 223 citations
  3. 3Chronic renal failure in lithium‐using geriatric patients: effects of lithium continuation versus discontinuation—a 60‐month retrospective study2012 · 37 citations
  4. 4The impact of modern treatment principles may have eliminated lithium-induced renal failure2013 · 51 citations
  5. 5Predicting Kidney Failure, Cardiovascular Disease and Death in Advanced CKD Patients2022 · 18 citations