What question did this study set out to answer?

To determine whether baseline serum hepcidin concentration measured shortly after intensive care unit admission identifies anaemic patients in whom intravenous iron reduces subsequent red blood cell transfusion requirements.

September 10, 2018Journal of Intensive CareOpen Access

Hepcidin predicts response to IV iron therapy in patients admitted to the intensive care unit: a nested cohort study

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Authors

OIon behalf of the IRONMAN Study investigators ELEdward LittonThe University of Western Australia SBStuart BakernLIGHT (United States)

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Implication

Randomized trial demonstrates that baseline hepcidin predicts transfusion reduction with intravenous iron in intensive care patients with anaemia, indicating a targeted treatment strategy.

Key Points

To determine whether baseline serum hepcidin concentration measured shortly after intensive care unit admission identifies anaemic patients in whom intravenous iron reduces subsequent red blood cell transfusion requirements.
Conducted a study nested within the multicenter randomized controlled IRONMAN trial comparing intravenous iron with placebo across intensive care units at four tertiary hospitals in Perth, Western Australia (ANZCTRN12612001249).
Enrolled critically ill patients with haemoglobin < 100 g/L within 48 hours of admission to the intensive care unit.
Assessed response to intravenous iron therapy versus placebo according to tertiles of baseline serum hepcidin concentration.
Baseline serum hepcidin concentration significantly predicted subsequent red blood cell transfusion requirement (p = 0.013).
Intravenous iron therapy was associated with a significant decrease in red blood cell transfusion requirement compared with placebo in a subgroup identified by baseline hepcidin levels.

Cite This Study

investigators et al. (2018) studied this question.

synapsesocial.com/papers/6a8a6d10754a5a619a723cd0 https://doi.org/10.1186/s40560-018-0328-2

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Implication

Randomized trial demonstrates that baseline hepcidin predicts transfusion reduction with intravenous iron in intensive care patients with anaemia, indicating a targeted treatment strategy.

Hepcidin predicts response to IV iron therapy in patients admitted to the intensive care unit: a nested cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

Hepcidin predicts response to IV iron therapy in patients admitted to the intensive care unit: a nested cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

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