Population
Goldblatt two-kidney, one-clip (2K1C) hypertensive rats and normotensive rats
Comparison
c-AUCB or HET-0016 vs Untreated 2K1C rats
Design
Preclinical
Authors
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Hypothesis-generating for sEH inhibition in renovascular hypertension models; leaves open clinical translation.
In a rat model of 2K1C hypertension, soluble epoxide hydrolase inhibition with c-AUCB lowers blood pressure by improving renal blood flow and pressure natriuresis.
Sporková et al. (2011) studied this question.
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