January 1, 1992Journal of Pharmacy and Pharmacology

Diuretic Action of the Novel Loop Diuretic Torasemide in the Presence of Angiotensin II or Endothelin-1 in Anaesthetized Dogs

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Why the study?

Does torasemide or furosemide improve renal haemodynamics and excretory responses in the presence of angiotensin II or endothelin-1 in anaesthetized dogs?

Population

Anaesthetized dogs

Comparison

Torasemide or furosemide administered as a bolus… vs Angiotensin II or endothelin-1 infusion alone…

Design

Preclinical

Authors

TUTakeshi UchidaHokkaido University KHKazutaka HayashiFujita Health University HKHideaki KidoHakodate Central General Hospital

Discussion

Member takes

Implication

Torasemide may reduce potassium wasting versus furosemide; animal data leave open translation to human cardiorenal management.

Structured PICO

Does torasemide or furosemide improve renal haemodynamics and excretory responses in the presence of angiotensin II or endothelin-1 in anaesthetized dogs?

Population

Anaesthetized dogs

Intervention

Torasemide (0.1 and 1 mg kg-1, i.v.) or furosemide (3 mg kg-1, i.v.) administered as a bolus during continuous intrarenal arterial infusion of angiotensin II (5 ng kg-1 min-1) or endothelin-1 (1.5 ng kg-1 min-1)

Comparator

Angiotensin II or endothelin-1 infusion alone, and comparison between torasemide and furosemide

Outcome

Renal haemodynamics (renal vascular resistance, renal blood flow, glomerular filtration rate) and excretory responses (urine flow, urinary excretion of sodium and potassium)surrogate

Torasemide and furosemide maintain sufficient diuretic and renal hemodynamic effects in the presence of angiotensin II or endothelin-1 in a canine model, with torasemide demonstrating less potassium wasting than furosemide.

Cite This Study

Uchida et al. (1992) studied this question.

synapsesocial.com/papers/6a8a6d5ac2b067567ebd57af https://doi.org/10.1111/j.2042-7158.1992.tb14360.x

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Diuretic Action of the Novel Loop Diuretic Torasemide in the Presence of Angiotensin II or Endothelin-1 in Anaesthetized Dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Diuretic Action of the Novel Loop Diuretic Torasemide in the Presence of Angiotensin II or Endothelin-1 in Anaesthetized Dogs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider