Population
23 rabbits (5 control, 5 angiotensin, 8 adrenalectomized, 5 unilateral renal denervation)
Comparison
Angiotensin infusion at 1 μg kg−1 min−1 for 40 min vs Normal saline infusion at a low rate for several…
Design
Preclinical
Follow-up
40 min
Authors
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Warrants caution against clinical extrapolation from rodent data; extends mechanistic insight into angiotensin natriuresis but leaves open human applicability.
Angiotensin induces natriuresis likely by inhibiting sodium reabsorption in the ascending limb of the loop of Henle, independent of adrenal hormone release or sympathetic nerve stimulation.
Healy et al. (1970) studied this question.
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