Key result
Urinary renin activity rises during oliguric acute renal failure and drops before urine output resolves.
Why the study?
A simple, rapid, and accurate method for measurement of urinary renin activity in humans was needed to understand its behavior in acute renal failure.
Population
5 patients with acute renal failure and 13 normal volunteers
Comparison
Acute renal failure patients vs normal volunteers
Design
Sequential observational study using radioimmunoassay
Authors
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May indicate impending oliguria resolution in ARF; hypothesis-generating for URA as recovery biomarker, needs prospective validation.
Observational (n=18)
A radioimmunoassay method for measuring urinary renin activity demonstrates that URA is elevated during the oliguric phase of acute renal failure.
Haley et al. (2008) conducted an observational in Acute renal failure (n=18). Acute renal failure vs. Normal volunteers was evaluated on Urinary renin activity (URA) levels. Urinary renin activity was elevated during the oliguric phase of acute renal failure and fell to low levels prior to resolution of oliguria, whereas normal volunteers maintained very low URA values.
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