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July 1, 1997European Respiratory Journal84 citationsOpen Access

Detection of adenovirus E1A DNA in pulmonary fibrosis using nested polymerase chain reaction

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Why the study?

Is adenovirus E1A DNA more prevalent in patients with idiopathic pulmonary fibrosis or collagen vascular disease-associated interstitial pneumonia compared to sarcoidosis?

Population

49 patients who underwent transbronchial lung biopsy, including 19 with idiopathic pulmonary fibrosis, 10…

Design

Cross-sectional

Authors

KKKazuyoshi KuwanoYNY NomotoRKRitsuko Kunitake

Discussion

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Overview

Adenovirus E1A is unlikely to be the primary etiological cause of IPF or CVD-IP, but latent infection may be reactivated by corticosteroid therapy.

Structured PICO

Is adenovirus E1A DNA more prevalent in patients with idiopathic pulmonary fibrosis or collagen vascular disease-associated interstitial pneumonia compared to sarcoidosis?

P
Population
49 patients who underwent transbronchial lung biopsy, including 19 with idiopathic pulmonary fibrosis (IPF), 10 with interstitial pneumonia associated with collagen vascular disease (CVD-IP), and 20 with sarcoidosis.
C
Comparator
Sarcoidosis patients (as a comparison group for IPF and CVD-IP)
O
Outcome
Presence of adenovirus E1A DNA detected by nested polymerase chain reaction (PCR) and in situ hybridization (ISH)surrogate

Adenovirus E1A is unlikely to be the primary etiological cause of IPF or CVD-IP, but latent infection may be reactivated by corticosteroid therapy.

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Cite This Study

Kuwano et al. (1997) studied this question.

synapsesocial.com/papers/6a8a6f8d788d49930fcbfe85https://doi.org/10.1183/09031936.97.10071445
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute and Chronic Human Adenovirus Pneumonia: Cellular and Extracellular Matrix Components1996 · 11 citations
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  3. 3Detection of Adenoviral Genome in the Myocardium of Adult Patients With Idiopathic Left Ventricular Dysfunction1999 · 316 citations
  4. 4Platelet Activating Factor Receptor and Intercellular Adhesion Molecule–1 Expression Increases in the Small Airway Epithelium and Parenchyma of Patients with Idiopathic Pulmonary Fibrosis: Implications for Microbial Pathogenesis2024 · 2 citations
  5. 5In Vivo Potential Effects of Adenovirus Type 5 E1A and E1B on Lung Carcinogenesis and Lymphoproliferative Inflammation2008 · 7 citations