8-hydroxy-deoxyguanosine as an independent prognostic factor in patients with metastatic colorectal cancer

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Introduction. Un traumatisme chirurgical peut stimuler la croissance de la tumeur pendant le cancer colorectal mtastatique la suite de la formation d'un dysfonctionnement mitochondrial. But. Nous avons analys l`importance clinique du marqueur molculaire de 8-hydroxydsoxyguanosine (8-OHdG) et l`influence oncologique d`ischmie chaude de parenchyme hpatique. Matriaux et mthodes. L'tude portait sur 89 patients atteints de cancer colorectal atteints de mtastase hpatique mtastatique traits l'Institut National du Cancer du Ministre de la Sant, Kiev, Ukraine, de 2015 2018, et 19 donneurs sous condition. Le taux de 8-hydroxy-dsoxyguanosine (8-OHDGu) dans l'urine des patients atteints de mCRC a t dtermin. La collecte d'urine a t effectue un jour avant l'opration ABSTRACT Introduction. Surgical injury can stimulate tumor growth in metastatic colorectal cancer (mCRC), due to mitochondrial dysfunction. The objective of the study was to analyze the clinical significance of the molecular marker of 8-hydroxydeoxyguanosine and the oncological influence of the liver parenchyma warm ischemia on the prognosis of mCRC. Materials and methods. The study involved 89 CRC patients with metachronous metastatic liver disease treated in The National Cancer Institute of the Ministry of Health, Kyiv, Ukraine, from 2015 till 2018, and 19 conditionally healthy donors. 8-Hydroxy-deoxyguanosine (8-OHdG) level in the urine of patients with mCRC was determined. Urine sampling was done 24-hours before and on day 3 after surgery. Measurements of the marker of oxidative DNA damage were repeated three times. The state of the hepatocyte detoxification energy system, the levels of superoxide radicals (O 2 -) in the tumour tissue were determined by electron