Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 1978Journal of Applied Physiology

Servo control of end-tidal CO2 in paralyzed animals

View Full Paper
Ask AI
Bookmark
Share

Population

Paralyzed animals used in experiments on neural respiratory control

Design

Preclinical

Authors

DSDavid SmithRMRobert R. MercerUniversity of North Carolina at Chapel HillFEF. L. EldridgeUniversity of North Carolina at Chapel Hill

Discussion

Loading...

Member takes

Implication

Validates servo-controlled PCO2 stability in animal preparations; extends respiratory control experiments while leaving human translation open.

Structured PICO

P
Population
Paralyzed animals used in experiments on neural respiratory control
I
Intervention
Electronic circuit using peak end-tidal CO2 signal from a rapid infrared CO2 analyzer to vary the motor rate of a fixed volume respirator in a closed-loop servo system
O
Outcome
Maintenance of constant PCO2 despite changes in cardiac output and venous CO2 returnsurrogate

The described closed-loop servo system effectively maintains constant PCO2 in paralyzed animals, facilitating experiments on neural respiratory control.

Cite This Study

Smith et al. (1978) studied this question.

synapsesocial.com/papers/6a8a7809e0083a7c2c437704https://doi.org/10.1152/jappl.1978.45.1.133
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of carbon dioxide oscillation in the control of respiration in the anesthetized dog.1989 · 3 citations
  2. 2Continuous carbon dioxide monitoring in the exhaled breath of mechanically ventilated rats2025 · 1 citations
  3. 3Open-loop analysis of Pax(x=CO2) oscillation in the dog.1984 · 3 citations
  4. 4Servo-Controlled Closed-Circuit Anaesthesia. A Method for the Automatic Control of Anaesthesia Produced by a Volatile Agent in Oxygen1984 · 4 citations
  5. 5Ventilatory response to intermittent inspired carbon dioxide1964 · 21 citations