Population
Single ventricular cells of guinea pigs
Comparison
Nicorandil (0.1 mM) vs Baseline (before application of nicorandil)
Design
Preclinical
Authors
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Animal data suggest nicorandil activates ventricular K+ channels; leaves open relevance to human cardiovascular therapy.
Nicorandil activates a small-conductance potassium channel in guinea pig ventricular cells without affecting calcium channels, explaining its electrophysiological effects.
Kakei et al. (1986) studied this question.
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