Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 3, 2008Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Retardation of Retinal Vascular Development in Apelin-Deficient Mice

View Full Paper
Ask AI
Bookmark
Share

Population

Apelin-deficient (apelin-KO) mice

Design

Preclinical

Follow-up

early postnatal period (first 2 postnatal weeks)

Authors

AKAtsushi KasaiMedical innovation (France)NSNorihito ShintaniWakayama Medical UniversityHKHideaki KatoTokyo University of Science

Discussion

Loading...

Member takes

Implication

Apelin/APJ signaling supports murine retinal angiogenesis; leaves open human relevance and therapeutic translation.

Structured PICO

P
Population
Apelin-deficient (apelin-KO) mice
I
Intervention
Apelin deficiency (genetic knockout)
O
Outcome
Retinal vascularization and ocular developmentsurrogate

Endogenous apelin/APJ signaling is essential for normal retinal vascularization and cooperates with VEGF and FGF2 in angiogenesis.

Cite This Study

Kasai et al. (2008) studied this question.

synapsesocial.com/papers/6a8a7e98b1e5d05ea8eca76chttps://doi.org/10.1161/atvbaha.108.163402
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues1997 · 418 citations
  2. 2Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms2002 · 356 citations
  3. 3Development and pathology of the hyaloid, choroidal and retinal vasculature2004 · 425 citations
  4. 4Impaired Heart Contractility in Apelin Gene–Deficient Mice Associated With Aging and Pressure Overload2007 · 311 citations