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March 19, 2010Investigative Ophthalmology & Visual Science

Apelin in Plasma and Vitreous and in Fibrovascular Retinal Membranes of Patients with Proliferative Diabetic Retinopathy

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Population

89 patients undergoing vitrectomy, including 55 with proliferative diabetic retinopathy and 34 with…

Design

Case-control

Authors

YTYong TaoUniversity of Electronic Science and Technology of ChinaQLQiang LüDeciphera Pharmaceuticals (United States)YJYanrong JiangNanjing University of Chinese Medicine

Discussion

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Implication

Elevated vitreous apelin may implicate the apelin/APJ system in neovascularization; hypothesis-generating and should not yet change practice.

Structured PICO

P
Population
89 patients undergoing vitrectomy, including 55 with proliferative diabetic retinopathy (study group) and 34 with idiopathic preretinal membranes or macular hole (control group).
O
Outcome
Concentrations of apelin and vascular endothelial growth factor (VEGF) in the vitreous and plasmasurrogate

The apelin/APJ system is upregulated in the vitreous and fibrovascular membranes of patients with proliferative diabetic retinopathy, suggesting a potential role in retinal neovascularization.

Cite This Study

Tao et al. (2010) studied this question.

synapsesocial.com/papers/6a9117f2d2f2d69b3a746235https://doi.org/10.1167/iovs.09-4466
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Retardation of Retinal Vascular Development in Apelin-Deficient Mice2008 · 136 citations
  2. 2Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders1994 · 3,808 citations
  3. 3An overview of the eye in diabetes2003 · 69 citations
  4. 4Angiogenic and Antiangiogenic Factors in Proliferative Diabetic Retinopathy2006 · 365 citations