Key result
Plasma apelin was significantly higher in diabetic patients with proliferative diabetic retinopathy (1.6 ng/ml) compared to controls (0.98 ng/ml) and diabetics without retinopathy (0.97 ng/ml).
Why the study?
Does plasma apelin concentration correlate with the presence of proliferative diabetic retinopathy and change after panretinal photocoagulation?
Observational (n=60)
Does plasma apelin concentration correlate with the presence of proliferative diabetic retinopathy and change after panretinal photocoagulation?
Absolute Event Rate: 1.6% vs 0.98%
Plasma apelin is elevated in proliferative diabetic retinopathy and may serve as a biomarker for ischemic retinal conditions.
Apelin elevation was associated with proliferative diabetic retinopathy; leaves open its potential as a biomarker requiring prospective validation.
PurposeThe study was designed to evaluate the role of apelin in diabetic retinopathy by measuring the concentration of plasma apelin and correlating the results between the control group, diabetic patients without and with retinopathy, and diabetic patients after treatment with panretinal photocoagulation (PRP).MethodsThe study included four groups: group A consisted of 20 normal individuals as the control group, group B consisted of 20 diabetic patients without retinopathy, group C consisted of 20 diabetic patients with untreated proliferative diabetic retinopathy (PDR), and group D consisted of the same patients of group C after treatment with PRP. Plasma apelin was measured in all groups and interpretation of the results was carried out.ResultsThe study revealed that plasma apelin increased significantly in diabetic patients with PDR (mean 1.6 ng/ml) compared with the control group (mean 0.98 ng/ml) and with diabetic patients without retinopathy (mean 0.97 ng/ml). Plasma apelin decreased nonsignificantly in diabetic patient with PDR after treatment with PRP (mean 1.2 ng/ml).ConclusionApelin plays an important role in retinal angiogenesis in diabetic patients; measurement of plasma apelin may be a good indicator for ischemic retinal condition, especially in the absence of other ischemic manifestations in the body.
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Nada et al. (2013) conducted an observational in Diabetic retinopathy (n=60). Proliferative diabetic retinopathy vs. Normal controls and diabetic patients without retinopathy was evaluated on Plasma apelin concentration. Plasma apelin was significantly higher in diabetic patients with proliferative diabetic retinopathy (1.6 ng/ml) compared to controls (0.98 ng/ml) and diabetics without retinopathy (0.97 ng/ml).
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