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January 1, 2006Journal of Intensive Care Medicine

Perioperative Effects and Safety of Nesiritide Following Cardiac Surgery in Children

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Why the study?

Does nesiritide administration during and after cardiac surgery cause hemodynamic compromise in pediatric patients with congenital heart disease?

Population

17 pediatric patients with congenital heart disease undergoing cardiac surgery

Design

Case_series

Follow-up

24 hours

Authors

JSJanet M. SimsicNationwide Children's HospitalMSMark A. ScheurerMilitary HospitalJTJoseph D. TobiasArkansas Children's Hospital

Discussion

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Implication

Supports nesiritide evaluation in pediatric cardiac surgery without intervention; hypothesis-generating and requires randomized confirmation.

Structured PICO

Does nesiritide administration during and after cardiac surgery cause hemodynamic compromise in pediatric patients with congenital heart disease?

P
Population
17 pediatric patients with congenital heart disease undergoing cardiac surgery
I
Intervention
Nesiritide loading dose (1 microg/kg) while on cardiopulmonary bypass followed by continuous infusion for 24 hours (0.01 microg/kg/min for 6 hours, then 0.02 microg/kg/min for 18 hours)
O
Outcome
Perioperative effects and safety (hemodynamic compromise, hypotension)safety

Nesiritide loading and continuous infusion appear safe and do not cause significant hemodynamic compromise in pediatric patients undergoing cardiac surgery.

Cite This Study

Simsic et al. (2006) studied this question.

synapsesocial.com/papers/6a8a823ce0083a7c2c437b2chttps://doi.org/10.1177/0885066605282532

Topics

Congenital heart disease adults
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Postoperative Course and Hemodynamic Profile After the Arterial Switch Operation in Neonates and Infants1995 · 1,007 citations
  2. 2Preliminary Experience With Nesiritide in the Pediatric Population2004 · 33 citations
  3. 3Hemodynamic and Renal Excretory Effects of Human Brain Natriuretic Peptide Infusion in Patients With Congestive Heart Failure1996 · 302 citations
  4. 4Receptors of Atrial Natriuretic Factor1992 · 300 citations
  5. 5Use of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass.1993 · 378 citations