Population
Isolated coronary, ulnar and basilar arteries of the pig
Comparison
Nitrendipine and six related 3-ester side chain… vs Different precontracting stimuli
Design
Preclinical
Authors
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Context-dependent selectivity in animal arteries cautions against clinical extrapolation; leaves open targeted human validation studies.
The vasorelaxant potency of dihydropyridines depends on the arterial bed, the precontracting stimulus, and the structure of their ester side chains.
Kojda et al. (1992) studied this question.
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