January 2, 1998Fundamental and Clinical Pharmacology
Regional differences in the vasorelaxant effects of nicorandil and amlodipine on isolated porcine coronary arteries
Population
Isolated porcine left anterior descending coronary artery ring preparations (proximal and distal parts)
Comparison
Nicorandil (10-10 M) and amlodipine (10-10 M) vs Comparison between proximal and distal segments…
Design
Preclinical
Authors
Discussion
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Implication
Regional selectivity in porcine coronaries is hypothesis-generating; human studies required before any clinical consideration.
Structured PICO
P
Population
Isolated porcine left anterior descending coronary artery ring preparations (proximal and distal parts)
I
Intervention
Nicorandil (10(-7)-10(-4) M) and amlodipine (10(-9)-10(-6) M)
C
Comparator
Comparison between proximal and distal segments, and between the two drugs
O
Outcome
Vasorelaxant effects on partially and maximally K(+)-depolarized ring preparationssurrogate
Nicorandil and amlodipine exhibit regional differences in their vasorelaxant effects on porcine coronary arteries, with nicorandil being more potent proximally and amlodipine distally.
Cite This Study
Tankó et al. (1998) studied this question.