Population
In vitro models including rat aorta, rat portal vein, perfused guinea pig hearts, and guinea pig papillary…
Comparison
Amlodipine vs Nifedipine
Design
Preclinical
Authors
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Warrants in vivo validation of amlodipine's profile; leaves open translation to human therapy.
Amlodipine exhibits potent, slow-onset, and voltage-dependent calcium channel blocking properties in vascular smooth muscle compared to nifedipine.
Burges et al. (1987) studied this question.
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