January 1, 1998Hypertension

Efficient Inhibition of the Development of Cardiac Remodeling by a Long-Acting Calcium Antagonist Amlodipine

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Why the study?

Does amlodipine prevent cardiac remodeling in spontaneously hypertensive rats compared to nifedipine?

Structured PICO

Does amlodipine prevent cardiac remodeling in spontaneously hypertensive rats compared to nifedipine?

Population

Spontaneously hypertensive 12-week-old rats

Intervention

Amlodipine 8 mg/kg per day, once a day for 12 weeks

Comparator

Nifedipine 24 mg/kg per day, three times a day for 12 weeks

Outcome

Cardiac remodeling assessed by left ventricular wall thickness, relative amounts of myosin heavy chain isoforms, and expressions of fetal type genes and type 1 collagen genesurrogate

In a hypertensive rat model, the long-acting calcium antagonist amlodipine effectively prevented morphological and biochemical cardiac remodeling, unlike the short-acting nifedipine.

Discussion

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Implication

Does not warrant preferential amlodipine use in hypertension; leaves open translation of differential remodeling effects from rat models.

Cite This Study

Yamazaki et al. (1998) studied this question.

synapsesocial.com/papers/6a7afd990b10e55359899a64 https://doi.org/10.1161/01.hyp.31.1.32

Topics

Hypertension management

View Full Paper

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Efficient Inhibition of the Development of Cardiac Remodeling by a Long-Acting Calcium Antagonist Amlodipine

Structured PICO

Discussion

Implication

Cite This Study

Topics

Efficient Inhibition of the Development of Cardiac Remodeling by a Long-Acting Calcium Antagonist Amlodipine

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider