Key result
Chronic administration of amlodipine lowered blood pressure and prevented cardiac hypertrophy in spontaneously hypertensive rats (p<0.01), and improved functional recovery after ischemia (p<0.01).
Why the study?
Does amlodipine reduce blood pressure, prevent cardiac hypertrophy, and protect against ischemia-reperfusion injury in hypertensive rats?
Population
Spontaneously hypertensive rats, and normotensive Wistar-Kyoto and Sprague-Dawley rats, 8 weeks old at the…
Comparison
Amlodipine 10 mg/kg/day orally for 30 weeks, or… vs Placebo
Design
Preclinical
Follow-up
30 weeks
Authors
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Preclinical rat data are hypothesis-generating; clinical translation to hypertension and ischemia remains untested.
Does amlodipine reduce blood pressure, prevent cardiac hypertrophy, and protect against ischemia-reperfusion injury in hypertensive rats?
p-value: p=<0.01
Prophylactic amlodipine lowers blood pressure, prevents cardiac hypertrophy, and exerts cardioprotective effects during ischemia in hypertensive rats.
Winifred G. Nayler (1988) studied Hypertension and ischemia. Amlodipine vs. Placebo was evaluated on Blood pressure, heart-to-body-weight ratio, functional recovery, and calcium ion gain (p=<0.01). Chronic administration of amlodipine lowered blood pressure and prevented cardiac hypertrophy in spontaneously hypertensive rats (p<0.01), and improved functional recovery after ischemia (p<0.01).
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