Why the study?
Does amlodipine prevent glomerular injury and slow the progression of chronic renal disease in experimental models of hypertension?
Population
Two experimental rat models of hypertension: 1) Adult male Munich Wistar rats with uninephrectomy and weekly…
Comparison
Amlodipine vs Normal chow (model 1) or no therapy (model 2)
Design
Preclinical
Follow-up
8 weeks (model 1) and 6 months (model 2)
Authors
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Amlodipine fails to protect glomeruli despite systemic BP reduction in hypertensive rats; challenges prior dihydropyridine data and leaves clinical translation open.
Does amlodipine prevent glomerular injury and slow the progression of chronic renal disease in experimental models of hypertension?
Despite effectively lowering systemic blood pressure, amlodipine does not prevent hypertensive nephrosclerosis or reduce glomerular injury in experimental rat models of hypertension.
Dworkin et al. (1996) studied this question.
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