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October 1, 1996British Journal of PharmacologyOpen Access

Effect of amlodipine on renin secretion and renin gene expression in rats

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Population

Normal normotensive rats and rats with renovascular hypertension

Design

Preclinical

Follow-up

up to 4 days

Authors

KSK. Th. SchrickerUniversitätsklinikum ErlangenMHMarlies HamannUniversity of RegensburgAMAndreas MacherUniversity of Zurich

Discussion

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Implication

May activate renin via calcium channel blockade in rats; leaves open human relevance and precludes practice change.

Structured PICO

P
Population
Normal normotensive rats and rats with renovascular hypertension (unilateral renal hypoperfusion induced by applying 0.2 mm left renal artery clips over four days, 2kidney-1 clip rats)
I
Intervention
Amlodipine at concentrations of 5, 15, and 45 mg kg-1
O
Outcome
Plasma renin activity and renal renin mRNA levelssurrogate

Inhibition of calcium channels by amlodipine stimulates renin secretion and renin gene expression in vivo in rat models.

Cite This Study

Schricker et al. (1996) studied this question.

synapsesocial.com/papers/6a834871dfd29b4838ca9cf4https://doi.org/10.1111/j.1476-5381.1996.tb15735.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Which factor mediates reno-renal control of renin gene expression?1993 · 30 citations
  2. 2Molecular cloning of rat renin cDNA and its gene.1987 · 164 citations
  3. 3Interrelation between renin mRNA levels, renin secretion, and blood pressure in two-kidney, one clip rats.1994 · 27 citations
  4. 4Role of Extra- and Intracellular Calcium and Calmodulin in Renin Release from Rat Kidney*1985 · 53 citations
  5. 5Influence of potassium, sodium, perfusion pressure, and isoprenaline on renin release induced by acute calcium deprivation1979 · 36 citations