Key result
Amlodipine significantly lowered systolic blood pressure and plasma aldosterone concentration (P<0.05) and suppressed cardiac mRNA expression of BNP, TGF-β1, and fibronectin in hypertensive rats.
Why the study?
Does amlodipine reduce cardiac gene expression of brain natriuretic peptide, transforming growth factor-β1 and fibronectin and lower plasma aldosterone in male stroke-prone spontaneously hypertensive rats?
Does amlodipine reduce cardiac gene expression of brain natriuretic peptide, transforming growth factor-β1 and fibronectin and lower plasma aldosterone in male stroke-prone spontaneously hypertensive rats?
In a rat model of hypertension, amlodipine attenuated cardiac damage markers and lowered plasma aldosterone, suggesting a protective mechanism beyond blood pressure lowering.
Does not support clinical adoption; leaves open whether amlodipine affects cardiac remodeling markers in human hypertension.
OBJECTIVES: Amlodipine, a calcium channel blocker (CCB), is one of the most common antihypertensive medicines in Japan. We evaluated whether the calcium channel blocker confers cardiac protection through the renin-angiotensin-aldosterone system in male stroke-prone spontaneously hypertensive rats (SHR-SP). METHODS: Fifteen week-old rats were divided into 2 groups: amlodipine group (3 mg/kg/day, n = 5) and control group (n = 5). KEY FINDINGS: The CCB lowered systolic blood pressure significantly (P < 0.05). Plasma aldosterone concentration in the amlodipine group was remarkably lower than in the control group (P < 0.05), but plasma renin activity and plasma angiotensin II concentration were not different between the two groups. The CCB also suppressed the mRNA expression of brain natriuretic peptide, transforming growth factor-β₁, and fibronectin extracted from the left ventricle. CONCLUSIONS: These results suggest that amlodipine attenuates cardiac damage by lowering plasma aldosterone concentration in hypertensive rats with developing arteriosclerosis.
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Harasawa et al. (2010) studied Hypertension (n=10). Amlodipine vs. Control was evaluated on Systolic blood pressure and plasma aldosterone concentration (p=<0.05). Amlodipine significantly lowered systolic blood pressure and plasma aldosterone concentration (P<0.05) and suppressed cardiac mRNA expression of BNP, TGF-β1, and fibronectin in hypertensive rats.
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