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June 1, 1998British Journal of PharmacologyOpen Access

T‐type and L‐type calcium channel blockers exert opposite effects on renin secretion and renin gene expression in conscious rats

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Why the study?

Do T-type and L-type calcium channel blockers have different effects on plasma renin activity and renin gene expression in rats?

Population

Male healthy Sprague-Dawley rats, rats with unilateral renal artery clips, and primary cultures of renal…

Design

Preclinical

Follow-up

4 days (in vivo)

Authors

CWCharlotte WagnerHuntsman Cancer InstituteBKBernhard K. KrämerUniversity of MannheimMHMarkus HinderNovartis (Switzerland)

Discussion

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Implication

Should not change CCB selection in hypertension; leaves open differential renin effects for human trials.

Structured PICO

Do T-type and L-type calcium channel blockers have different effects on plasma renin activity and renin gene expression in rats?

P
Population
Male healthy Sprague-Dawley rats, rats with unilateral renal artery clips (2K-1C), and primary cultures of renal juxtaglomerular cells
I
Intervention
T-channel blocker mibefradil (5, 15, and 45 mg/kg/day for 4 days in vivo; 0.1-10 microM in vitro) or L-channel blocker amlodipine (5, 15, and 45 mg/kg/day for 4 days in vivo; 0.1-10 microM in vitro)
O
Outcome
Plasma renin activity (PRA) and kidney renin mRNA levelssurrogate

T-type calcium channel blockers inhibit renin secretion and gene expression in vivo, whereas L-type calcium channel blockers stimulate the renin system, suggesting indirect in vivo effects.

Cite This Study

Wagner et al. (1998) studied this question.

synapsesocial.com/papers/6a86ac893f44447e627cab5fhttps://doi.org/10.1038/sj.bjp.0701861
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Divergent Effects of Dihydropyridine and Phenylalkylamine Calcium Channel Antagonist Classes on Autonomic Function in Human Hypertension1995 · 74 citations
  2. 2Regulation of Renin Secretion and Renin Synthesis by Second Messengers in Isolated Mouse Juxtaglomerular Cells1991 · 50 citations
  3. 3Effect of amlodipine on renin secretion and renin gene expression in rats1996 · 26 citations
  4. 4Tonic stimulation of renin gene expression by nitric oxide is counteracted by tonic inhibition through angiotensin II.1995 · 56 citations
  5. 5Chronic Treatment with the CA2+Channel Inhibitor RO 40-5967 Potentiates Endothelium-Dependent Relaxations in the Aorta of the Hypertensive Salt Sensitive Dahl Rat1994 · 25 citations