Why the study?
Does the combination of a calcium-enriched diet and amlodipine improve arterial blood pressure and cardiac hypertrophy in spontaneously hypertensive rats?
Population
Male spontaneously hypertensive rats (SHR) weaned at three weeks
Comparison
Calcium-enriched diet alone or combined with… vs Normal calcium diet alone or combined with…
Design
Preclinical, randomized in four groups
Follow-up
22 weeks (until 25 weeks of age)
Authors
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May blunt dietary calcium's BP effect without curbing hypertrophy in rats; leaves open human relevance and CCB-diet interactions.
Does the combination of a calcium-enriched diet and amlodipine improve arterial blood pressure and cardiac hypertrophy in spontaneously hypertensive rats?
The combination of dietary calcium and amlodipine does not provide synergistic benefits for blood pressure control or prevention of cardiac hypertrophy in a hypertensive rat model.
Civantos et al. (2003) studied this question.
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