Key result
Alpha-methyldopa, but not hydralazine, reversed cardiac hypertrophy and improved calcium transport by cardiac sarcoplasmic reticulum in spontaneously hypertensive rats.
Why the study?
Does antihypertensive therapy with hydralazine or alpha-methyldopa improve calcium transport by cardiac sarcoplasmic reticulum in spontaneously hypertensive rats?
Does antihypertensive therapy with hydralazine or alpha-methyldopa improve calcium transport by cardiac sarcoplasmic reticulum in spontaneously hypertensive rats?
Reversal of cardiac hypertrophy is required for improvement in calcium transport by cardiac sarcoplasmic reticulum after antihypertensive therapy in spontaneously hypertensive rats.
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Reversal of hypertrophy required for sarcoplasmic reticulum calcium transport gains; leaves open translation beyond rat models.
Limas et al. (1980) studied Hypertension and cardiac hypertrophy. Alpha-methyldopa or hydralazine vs. Untreated SHRs and normotensive rats was evaluated on Calcium transport capacity and regression of cardiac hypertrophy. Alpha-methyldopa, but not hydralazine, reversed cardiac hypertrophy and improved calcium transport by cardiac sarcoplasmic reticulum in spontaneously hypertensive rats.
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