Why the study?
Although adding hydrochlorothiazide to furosemide improved diuretic response in the CLOROTIC trial, whether these effects differ across the eGFR spectrum was unknown.
Does the addition of hydrochlorothiazide to furosemide improve diuretic response across the eGFR spectrum in patients with acute heart failure?
Does the addition of hydrochlorothiazide to furosemide improve diuretic response across the eGFR spectrum in patients with acute heart failure?
The addition of eGFR-adjusted doses of oral hydrochlorothiazide to loop diuretics improves diuretic response in acute heart failure regardless of baseline renal function.
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HCTZ addition improves diuretic response across eGFR spectrum in AHF; leaves open safety optimization in low-eGFR subgroups.
Trullàs et al. (2023) studied this question.
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