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September 30, 2008CirculationOpen Access

Tight Heart Rate Control Reduces Secondary Adverse Events in Patients With Type B Acute Aortic Dissection

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Why the study?

Does tight heart rate control reduce aortic events and surgical requirement in patients with acute type B aortic dissection?

Population

171 patients with acute type B aortic dissection medically treated and controlled to lower blood pressure…

Comparison

Tight heart rate control based on average HR at… vs Conventional heart rate control

Design

Cohort

Follow-up

median 27.0 months

Authors

KKKazuhisa KodamaKNKazuhiro NishigamiTSTomohiro Sakamoto

Discussion

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Overview

Tight HR control was associated with fewer aortic events in type B dissection; hypothesis-generating and requires randomized confirmation before practice change.

Structured PICO

Does tight heart rate control reduce aortic events and surgical requirement in patients with acute type B aortic dissection?

P
Population
171 patients with acute type B aortic dissection medically treated and controlled to lower blood pressure under 120 mm Hg
I
Intervention
Tight heart rate control (<60 beats per minute; mean HR 56.6+/-3.1 bpm) based on average HR at 3, 5, and 7 days after onset
C
Comparator
Conventional heart rate control (>=60 beats per minute; mean HR 71.7+/-8.2 bpm)
O
Outcome
Frequency of aortic events (composite of late organ or limb ischemia, aortic rupture, recurrent dissection, and aortic expansion of >5 mm) and surgical requirementcomposite

Tight heart rate control (<60 bpm) significantly reduces the risk of secondary aortic events and the need for surgery in patients with medically treated type B acute aortic dissection.

Cite This Study

Kodama et al. (2008) studied this question.

synapsesocial.com/papers/6a8a845c755d28965dfd6efchttps://doi.org/10.1161/circulationaha.107.755801
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Drug Therapy of Dissecting Aortic Aneurysms1968 · 21 citations
  2. 2The Prognosis in Aortic Dissection (Dissecting Aortic Hematoma or Aneurysm)1965 · 65 citations
  3. 3Progression of Aortic Dilatation and the Benefit of Long-Term β-Adrenergic Blockade in Marfan's Syndrome1994 · 1,076 citations
  4. 4Intravenous Labetalol in Acute Aortic Dissection1987 · 35 citations
  5. 5Partial Thrombosis of the False Lumen in Patients with Acute Type B Aortic Dissection2007 · 717 citations