Why the study?
Do neuronal uptake-1 inhibitors reduce the incidence of ventricular fibrillation and myocardial contracture in ischemic and anoxic rat hearts?
Population
Perfused rat hearts and anesthetized rats in vivo subjected to ischemic or anoxic conditions
Comparison
Neuronal uptake-1 inhibitors and norepinephrine… vs Untreated ischemic or anoxic conditions (implied)
Design
Preclinical
Authors
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Supports uptake-1 inhibition in ischemic arrhythmia models; leaves open translation to human therapy.
Do neuronal uptake-1 inhibitors reduce the incidence of ventricular fibrillation and myocardial contracture in ischemic and anoxic rat hearts?
Uptake-1 inhibitors protect rat hearts against ischemia/reperfusion- and anoxia/reoxygenation-induced arrhythmias, partly by inhibiting locally mediated norepinephrine release.
Du et al. (1998) studied this question.
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