Key result
Electrical field stimulation and myocardial ischemia temporarily increased the density of uptake1 carrier proteins in isolated rat hearts, enhancing norepinephrine transport capacity.
Population
Isolated perfused rat hearts
Comparison
Electrical field stimulation and stop-flow… vs Control hearts (nonischemic, non-stimulated)
Design
Preclinical
Authors
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Does not support clinical translation; hypothesis-generating for ischemia-related sympathetic changes in humans.
Absolute Event Rate: 210% vs 134%
p-value: p=< .005
Both electrical field stimulation and myocardial ischemia temporarily increase the density of uptake1 carrier proteins in isolated rat hearts, which may enhance norepinephrine transport capacity.
Ungerer et al. (1996) studied Myocardial ischemia. Electrical field stimulation and stop-flow ischemia vs. Control hearts (nonischemic/unstimulated) was evaluated on Cardiac density of uptake1 carriers (Bmax) (p=< .005). Electrical field stimulation and myocardial ischemia temporarily increased the density of uptake1 carrier proteins in isolated rat hearts, enhancing norepinephrine transport capacity.
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