Angiographic predictors of reocclusion after thrombolysis: Results from the thrombolysis in myocardial infarction (TIMI) 4 trial
Why the study?
Do specific angiographic lesion characteristics at 90 minutes predict infarct-related artery reocclusion by 18 to 36 hours in patients with acute myocardial infarction treated with thrombolysis?
Population
278 patients with acute myocardial infarction treated with thrombolytic therapy
Comparison
Presence of specific angiographic lesion… vs Absence of these angiographic characteristics
Design
Cohort, Patients were randomized to receive either anisoylated plasminogen…
Follow-up
18 to 36 hours
Authors
Discussion
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Member takes
Implication
Early angiographic features may flag higher reocclusion risk post-thrombolysis; hypothesis-generating for targeted strategies.
Structured PICO
Do specific angiographic lesion characteristics at 90 minutes predict infarct-related artery reocclusion by 18 to 36 hours in patients with acute myocardial infarction treated with thrombolysis?
P
Population
278 patients with acute myocardial infarction treated with thrombolytic therapy
I
Intervention
Presence of specific angiographic lesion characteristics (TIMI 2 flow, ulceration, collaterals, percent stenosis) at 90 minutes post-thrombolysis
C
Comparator
Absence of these angiographic characteristics
O
Outcome
Infarct-related artery reocclusion by 18 to 36 hourssurrogate
Angiographic variables such as TIMI grade 2 flow, ulceration, collateral vessels, and greater percent diameter stenosis at 90 minutes after thrombolysis can identify patients at higher risk for early infarct-related artery reocclusion.
Cite This Study
Gibson et al. (1995) studied this question.