Why the study?
Does high-rate pacing prevent dofetilide-induced Torsade de Pointes and reduce variability of repolarization in dogs with chronic AV block?
Population
7 dogs with chronic atrioventricular block
Comparison
High-rate pacing during dofetilide administration vs Low-rate pacing during dofetilide administration
Design
Preclinical
Authors
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High-rate pacing should not change clinical TdP management; leaves open translation from canine chronic AV block models.
Does high-rate pacing prevent dofetilide-induced Torsade de Pointes and reduce variability of repolarization in dogs with chronic AV block?
High-rate pacing increases repolarization reserve and prevents drug-induced Torsade de Pointes in a canine model of chronic AV block, with arrhythmic risk reflected by short-term variability of repolarization.
Oosterhoff et al. (2010) studied this question.
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