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January 1, 2013American Journal of NephrologyOpen Access

Heart Rate Variability Is a Predictor of Mortality in Chronic Kidney Disease: A Report from the CRIC Study

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Why the study?

Is heart rate variability associated with renal outcomes, cardiovascular outcomes, or mortality in patients with chronic kidney disease?

Population

3,245 participants with chronic kidney disease (CKD) from the Chronic Renal Insufficiency Cohort (CRIC) Study

Design

Cohort

Follow-up

median 4.2 years

Authors

PDPaul E. DrawzDBDenise C. BabineauCBCarolyn Brecklin

Discussion

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Overview

RMSSD extremes associated with higher mortality in CKD but not renal/CV outcomes; hypothesis-generating and leaves open predictive utility.

Structured PICO

Is heart rate variability associated with renal outcomes, cardiovascular outcomes, or mortality in patients with chronic kidney disease?

P
Population
3,245 participants with chronic kidney disease (CKD) from the Chronic Renal Insufficiency Cohort (CRIC) Study
I
Intervention
Heart rate variability (HRV) measured by SDNN and RMSSD from a baseline 10-second electrocardiogram
O
Outcome
Renal outcomes, cardiovascular outcomes, and all-cause mortalityhard clinical

In patients with chronic kidney disease, both low and high heart rate variability measured by RMSSD are associated with an increased risk of all-cause mortality, but not with renal or cardiovascular outcomes.

Cite This Study

Drawz et al. (2013) studied this question.

synapsesocial.com/papers/6a8a8affb4e829b19bd48ba6https://doi.org/10.1159/000357200
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lower Heart Rate Variability Is Associated With the Development of Coronary Heart Disease in Individuals With Diabetes2002 · 305 citations
  2. 2Heart Rate Variability during Chronic Hemodialysis and after Renal Transplantation1999 · 53 citations
  3. 3Higher Levels of Inflammation Factors and Greater Insulin Resistance Are Independently Associated with Higher Heart Rate and Lower Heart Rate Variability in Normoglycemic Older Individuals: The Cardiovascular Health Study2008 · 79 citations
  4. 4Effects of Moderate and Vigorous Physical Activity on Heart Rate Variability in a British Study of Civil Servants2003 · 299 citations
  5. 5Cardiovascular autonomic function is associated with (micro-)albuminuria in elderly Caucasian sujects with impaired glucose tolerance or type 2 diabetes: the Hoorn Study.2000 · 46 citations