September 24, 2011BMC Medical GeneticsOpen Access

Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits

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Population

11,693 individuals (2,548 adolescents and 9,145 adults) from 4,986 Australian twin families

Design

Cross-sectional

Authors

RMRita P. S. MiddelbergScripps Research Institute MFManuel A. R. FerreiraBroad Institute AHAnjali K. HendersThe University of Queensland

Discussion

Member takes

Implication

Hypothesis-generating for shared genetic effects on lipids and CRP; requires prospective validation before any clinical consideration.

Structured PICO

Population

11,693 individuals (2,548 adolescents and 9,145 adults) from 4,986 Australian twin families

Intervention

Genome-wide association analysis (GWAS)

Outcome

Allelic associations for multiple biochemical traits (serum alanine aminotransferase, aspartate aminotransferase, butrylycholinesterase, C-reactive protein, ferritin, gamma glutamyltransferase, glucose, HDL, insulin, LDL, triglycerides, uric acid) and body-mass indexsurrogate

GWAS identified pleiotropic genetic loci (LPL, TOMM40/APOE, OASL) that simultaneously influence multiple cardiovascular risk markers including lipids and CRP.

Cite This Study

Middelberg et al. (2011) studied this question.

synapsesocial.com/papers/6a8a903b0f137e402b3399ab https://doi.org/10.1186/1471-2350-12-123

Topics

Women and heart disease

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Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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