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March 27, 2014Pediatric ObesityOpen Access

In children and adolescents, subcutaneous adiposity was the most significant covariate for HOMA (P < 0.001) and TG (P = 0.001), whereas in adults, waist-height ratio (P < 0.001), VF/SubQF ratio (P = 0.001) and BMI (P = 0.02) were most significant for HOMA.

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Population

999 members of 111 extended Midwestern US families of Northern European origin

Design

Cohort

Authors

OAOmar AliDCDiana CerjakJKJack W. Kent

Discussion

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Overview

Subcutaneous adiposity may inform pediatric HOMA/TG assessment; leaves open prospective validation of age-specific fat measures for cardiometabolic risk.

Structured PICO

P
Population
999 members of 111 extended Midwestern US families of Northern European origin
O
Outcome
Homeostasis model assessment (HOMA), high-density lipoprotein cholesterol (HDL-c), plasma triglycerides (TG) and low-density lipoprotein cholesterol (LDL-c)surrogate

Subcutaneous adiposity at the waist is a more significant predictor of metabolic syndrome traits in children and adolescents compared to adults, where visceral fat and waist-height ratio are more prominent.

Cite This Study

Ali et al. (2014) studied this question.

synapsesocial.com/papers/6a8a91d90f137e402b339a7ahttps://doi.org/10.1111/j.2047-6310.2014.218.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abdominal Adiposity and Total Body Fat as Predictors of Cardiometabolic Health in Children and Adolescents With Obesity2020 · 50 citations
  2. 2Cardiometabolic Risk Variables in Preadolescent Children: A Factor Analysis2017 · 25 citations
  3. 3Sex-specific associations of adiposity with cardiometabolic traits in the UK: A multi–life stage cohort study with repeat metabolomics2022 · 15 citations
  4. 4Adiposity Distribution and Cardiometabolic Risk in Children and Adolescents: Clinical Implications and Contributing Factors2026
  5. 5Factors beyond Body Mass Index Associated with Cardiometabolic Risk among Children with Severe Obesity2024 · 4 citations