Cardiovirulent Coxsackievirus B3 induces higher iNOS expression in the heart compared to attenuated virus, supporting a cytotoxic role for nitric oxide in the pathogenesis of viral myocarditis.
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iNOS upregulation in murine CVB3 myocarditis suggests NO cytotoxicity; hypothesis-generating for human translation, no practice change yet.
Bevan et al. (2001) studied this question.
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