Population
Mice homozygous for a disrupted NOS2 allele (NOS2(-/-)) and wild-type mice infected with Coxsackievirus
Comparison
NOS2 gene disruption (NOS2(-/-) mice) vs Wild-type mice
Design
Preclinical
Authors
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NOS2 protects against severe Coxsackievirus myocarditis in mice; leaves open any therapeutic role in human disease.
Inducible nitric oxide synthase (NOS2) plays a crucial protective role in the host response to Coxsackievirus myocarditis in mice.
Zaragoza et al. (1998) studied this question.
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