October 6, 2019Thrombosis and Haemostasis
Venous Thromboembolism despite Ongoing Prophylaxis after Fast-Track Hip and Knee Arthroplasty: A Prospective Multicenter Study of 34,397 Procedures
Why the study?
Recent studies found low 90-day VTE incidence with in-hospital thromboprophylaxis after fast-track THA and TKA, but a subgroup still developed VTE despite prophylaxis.
What is the incidence and what are the risk factors for VTE despite ongoing thromboprophylaxis after fast-track THA/TKA?
Population
34,397 fast-track THA and TKA procedures without preoperative potent anticoagulant use
Design
Prospective unselected multicenter cohort study
Follow-up
90-day
Authors
Discussion
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Member takes
Implication
VTE risk persists despite in-hospital prophylaxis after fast-track THA/TKA; leaves open optimal duration and targeted extended regimens.
Structured PICO
What is the incidence and what are the risk factors for VTE despite ongoing thromboprophylaxis after fast-track THA/TKA?
P
Population
34,397 procedures in patients undergoing fast-track total hip and knee arthroplasty (THA/TKA), excluding those with preoperative use of potent anticoagulants.
I
Intervention
Ongoing thromboprophylaxis
O
Outcome
Incidence and risk for venous thromboembolism (VTE) despite ongoing thromboprophylaxis at 90 dayshard clinical
VTE despite ongoing thromboprophylaxis after fast-track THA/TKA is rare (0.09%) but strongly associated with advanced age and extreme BMI.
Cite This Study
Petersen et al. (2019) studied this question.