Key result
In-hospital thromboprophylaxis only for patients with length of stay ≤5 days after fast-track THA and TKA resulted in a 0.84% (95% CI 0.62-1.15%) 90-day incidence of symptomatic thromboembolic events.
Why the study?
Does in-hospital only thromboprophylaxis prevent symptomatic thromboembolic events in patients undergoing fast-track THA and TKA with LOS ≤5 days?
Population
4924 consecutive unselected unilateral primary total hip arthroplasty and total knee arthroplasty in…
Design
Cohort
Follow-up
90 days
Authors
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Low incidence with in-hospital prophylaxis alone in fast-track THA/TKA supports hypothesis that prolonged use may be unnecessary; leaves open need for RCTs.
Cohort (n=4,924)
Yes
Does in-hospital only thromboprophylaxis prevent symptomatic thromboembolic events in patients undergoing fast-track THA and TKA with LOS ≤5 days?
In-hospital thromboprophylaxis only is associated with a low incidence of TEE and VTE in fast-track THA and TKA patients with LOS ≤5 days, suggesting prolonged prophylaxis may not be necessary.
Jørgensen et al. (2013) conducted a cohort in fast-track total hip and knee arthroplasty (n=4,924). Prophylaxis with low-molecular-weight heparin or factor Xa-inhibitors only during hospitalisation was evaluated on symptomatic thromboembolic events (TEEs) ≤90 days postoperatively (95% CI 0.62 to 1.15). In-hospital thromboprophylaxis only for patients with length of stay ≤5 days after fast-track THA and TKA resulted in a 0.84% (95% CI 0.62-1.15%) 90-day incidence of symptomatic thromboembolic events.
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